Monthly Webinar Overview
Hey there Sigmates! Welcome to the Webinar Overview of February 2021. This is a new initiative the board has started in corona times.
Stay tuned for the interesting, free webinars from great scientists from all over the world!
Deuterium in the 21st Century, Use in Medicinal Chemistry and Synthetic Methods
When: Tuesday March 2nd, 16.00
Who: Dr. THomas Jennquin from Ypso-Facto
Where: Scientific Update, register via this link.
this webinar is also available on-demand if you register.
Ninety years after its discovery, Deuterium is in the spotlights. Since the beginning of the 21st century, a number of biotechnology companies have successfully explored its potential in drug candidates and generated intellectual property. This approach has been ‘’validated’’ by the first approval by the FDA of a deuterated drug in 2017. This renewed interest has also triggered an acceleration of the development of new methods for the synthesis of deuterated drugs.
In this webinar, we will first briefly go over the history of deuterium and its use over the years. We will then explore why it has been increasingly used in medicinal chemistry and how ‘’leaving the deuterium in the drug’’ can reduce the toxicity, the metabolization of a drug and overall improve its pharmacokinetic profile. We will then focus on the synthesis of deuterated compounds from the historical methods to the more recent ones and highlight the challenges that remain. Lastly, we will show how a chemical engineering approach could bring a better understanding and control of the deuteration reactions and allow for the large-scale production of complex deuterated drugs.
The RNA world
When: Thursday, March 4th, 20.00
Who: Jack Szostak, Professor of Chemistry and Chemical Biology, Harvard University - Nobel Prize Winner in 2009!
Where: Youtube Livestream
In this episode we will talk with Jack Szostak. He was awarded the Nobel Prize in Physiology or Medicine 2009 for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase.
Jack Szostak studies the chemical and physical processes that gave rise to biological evolution on the early Earth. His laboratory is trying to build a synthetic protocell that undergoes Darwinian evolution, potentially leading to the spontaneous emergence of genomically encoded catalysts and structural molecules.
The Wonderful World of Scanning Electrochemical MIcroscopy (SECM)
When: Wednesday, March 10th, 17.00
Who: Dr. Janine Mauzeroll
Where: Insidescientific, register via this link
In this webinar, Dr. Janine Mauzeroll will discuss the fundamentals, critical experimental parameters and recent applications for scanning electrochemical Microscopy (SECM).
In its simplest form, SECM is a scanning probe technique in which a small-scale electrode is scanned across an immersed substrate while recording the current response. This response is dependent on both the surface topography and the electrochemical activity of the substrate. Consequently, using an array of operational modes, a wide variety of substrates and experimental systems can be characterized. The strength of SECM lies in its ability to quantify material flux from a surface with a high spatial and temporal resolution. It has been used in a variety of applications fields.
Dr. Janine Mauzeroll will first describe the fundamentals of SECM, including the required instrumentation and the principles of the most frequently used operational modes. Following this basic understanding of SECM principles, she will then move towards a comprehensive summary of the critical parameters for any SECM experiment. Specifically, she will discuss in detail redox mediators, probes, and solvent systems that are used in SECM experiments. Finally, she will present recent applications of SECM with an emphasis on her work in the last five years related to material characterization, corrosion and batteries.
Chemists Make the Best Homebrewers
When: Tuesday March 16th, 17.00
Who: A. Hunt, PhD student working in the lab of Michael Jewett in the department of Chemical and Biological Engineering at Northwestern University.
Where: AIChe Academy, register via this link
The rapid discovery and development of antibody drugs against novel targets has never been more important. While advances in synthetic selection and antibody repertoire mining have enabled the rapid identification of candidate binders, the expression and evaluation of candidate antibodies still remains a major bottleneck in the discovery pipeline due to labor-intensive steps and process-throughput mismatches. This webinar details an innovative workflow that enables the expression and evaluation of hundreds of antibodies in a single experiment.
The new workflow consists of a cell-free DNA assembly step to generate antibody expression templates, a modified E. coli cell-free protein synthesis (CFPS) system to express antibodies, and the AlphaLISA protein-protein interaction assay to evaluate binding. The workflow is capable of processing ten times the number of candidates in less than one-third of the time when compared to comparable cell-based methods.
Scientists, professors, and researchers in the pharmaceutical sector should attend this webinar to learn more about these innovative tools. You’ll learn:
- The importance of neutralizing antibodies as a therapeutic modality for emerging viral pathogens
- The bottlenecks in current antibody discovery pipelines
- The basics of CFPS and how it can be used to screen and manufacture antibodies
- How process bottlenecks can be alleviated with CFPS combined with an Echo® acoustic liquid handler
Accelerating Antibody Discovery with Cell Free Protein Synthesis and Automation
When: Wednesday March 17th, 20.00
Who: Brian Guthrie of Cargill from American Chemical Society
Where: American Chemical Society, register via this link
Discover the major ways that homebrew can be made and learn timely tips for getting started and improving your methods during this free interactive broadcast. Not a homebrewer? No problem, join live to understand how you can integrate brewing concepts in your chemistry discussions and classrooms.
This ACS Webinar is moderated by Brian Guthrie of Cargill and co-produced with the ACS Division of Agricultural & Food Chemistry.
Ultrasensitive Immunoassays: The Power of Single Molecule Counting Technology
When: Wednesday March 31st, 16.00
Where: Labroots.com, register via this link
As scientists continue to expand the utility of biomarkers in basic and applied life science research, advances in immunoassay technologies further empower these efforts by improving the way key markers of health and disease are identified, characterized, and measured in biological samples. In particular, recent advances of ultrasensitive assay platforms strive to enable researchers to better understand the importance and application of both novel and existing biomarkers by detecting them at levels never before possible. In doing so, scientists are able to more confidently draw meaningful conclusions regarding molecules important in early disease onset and characterize the modulation of efficacy and safety biomarkers in clinical trials, potentiating future advances in the development of therapeutics.
MilliporeSigma is excited to invite you to our upcoming virtual symposium on the power of Single Molecule Counting (SMC™) ultrasensitive immunoassay technology on March 31, 2021. Whether you are already working on the cutting edge of biomarker research, or are seeking to learn how immunoassays can enable your next scientific breakthrough, join our symposium to:
- Learn about the relevance and utility of ultrasensitive immunoassays in life science research
- Understand key benefits of the Single Molecule Counting (SMC™) ultrasensitive immunoassay platform
- Explore all the ways to enjoy the power of SMC™ technology, including highly verified shelf kits, comprehensive homebrew assay development capabilities, or white-glove services offered through our expert Custom Assay and Sample Testing (CAST) team
- Learn from leading scientists how the SMC™ platform has empowered discoveries in drug-induced immunogenicity, vaccine development, pharmacokinetics, and miRNA-based therapies
- Network with the SMC™ user community and our in-house technology experts to spark new ideas
Webinars on Demand
Below we listed some webinars that are available on demand, and thus can be watched at any time you’d like.
Webinar distance learning is a webinar from Radboud University about studying during the corona crisis. It is meant to teach you how to bring structure into your life and create an overview of everything you have to do. Moreover, it can help you balance an online and offline life and cope with worrying thoughts. You can sign up for the webinar as a ‘course’ in Osiris called ASB-DISTLEARNING. Then you can find the webinar in Brightspace.
Chemistry World offers many webinars on chemistry
Thermofisher offers many webinars on MLS-related topics.
News medical offers many webinars on Life Sciences topics
Insidescientific offers many webinars on Molecular Biology and Medicine-related topics